By J. D. Rowley (auth.), Prof. Dr. T. Büchner, Prof. Dr. G. Schellong, Prof. Dr. J. Ritter, Priv. Doz. Dr. U. Creutzig, Prof. Dr. W. Hiddemann, Priv. Doz. Dr. B. Wörmann (eds.)
For 10 years the booklet sequence Acute Leukemias has been offering updates at the speedy growth being made across the world touching on this workforce of ailments. The 5th quantity ordinarily addressed experimental methods, however the current factor provides either healing and prognostic features of the latest effects from significant multicenter scientific trials. extra chapters document new tendencies in leukemia phone biology,the tracking of minimum residual affliction, and secondary leukemias, in addition to new antileukemic medications, antimicrobial thoughts, and using cytokines. The mixed efforts opposed to acute leukemias defined during this e-book clarify the new advancements within the final result of sufferers struggling with acute leukemias.
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Extra resources for Acute Leukemias VI: Prognostic Factors and Treatment Strategies
17. inversion 16 chromosome in acute myelogenous leukemia. Blood 83,1750-1756,1994 Berger R, Bernheim A, Ochoba-Noguera ME, Daniel M-T, Valensi F, Siguax F, Flandrin G, Boiron M: Prognostic significance of the chromosomal abnormalities in acute nonlymphocytic leukemia: A study of 343 patients. Cancer Genet Cytogenet28,293-299,1987 Swans bury GJ, Lawler SD, Alimena G, Arthur D, Berger R, Van Den Berghe H, Bloomfield CD, De la Chappelle A, Dewald G, Garson OM, Hagemeijer A, Mitelman F, Rowley JD, Sakurai M: Long-term survival in acute myelogenous leukemia.
The fusion genes are especially suited for RT-PCR, a technique in which the fusion mRNA is copied into cDNA and then, with appropriate primers from each gene, the fusion gene is amplified by PCR. Rased on the position of the primers, the size(s) of the expected fusion product is known and can be compared with that actually obtained. Our increasing precision in identifying the genetic changes in the malignant cells comes at a most opportune time, because physicians will soon be in a position to use targeted therapy aimed at the specific genetic defect in the malignant cells.
I. +21 chromosome aberrations might turn out to be of prognostic value. Acknowledgments. We thank PD Dr. Wandt, Klinikum der Stadt Nurnberg, Dr. Lengfelder, Klinikum der Stadt Mannheim, Dr. Gruneisen, Stadtisches Krankenhaus Berlin-Neukolln, Prof. Dr. Hiddemann, PD. Dr. Wormann, Universitat 14 Gottingen, Prof. Dr. Diehl, Universitat Kiiln, Prof. Dr. Wagner, Dr. Schwieder, Medizinische Universitat zu Lubeck, Prof. Dr. Andreesen, Dr. Hollerbach, Universitat Regensburg, Prof. Dr. Thiel, Universitatsklinikum Benjamin Franklin Berlin, Prof.
Acute Leukemias VI: Prognostic Factors and Treatment Strategies by J. D. Rowley (auth.), Prof. Dr. T. Büchner, Prof. Dr. G. Schellong, Prof. Dr. J. Ritter, Priv. Doz. Dr. U. Creutzig, Prof. Dr. W. Hiddemann, Priv. Doz. Dr. B. Wörmann (eds.)