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New PDF release: Aging: Modern Theories and Therapies (New Biology)

By Joseph Panno

ISBN-10: 0816068461

ISBN-13: 9780816068463

ISBN-10: 1438133642

ISBN-13: 9781438133645

Makes an attempt to appreciate the getting older approach have generated quite a few theories yet few useful cures. conventional cures deal with age-related ailments corresponding to melanoma and arthritis yet don't opposite the getting older method itself. a standard pattern in gerontology is to go looking for genes that experience a demonstrable influence on lifespan, the so-called durability genes. Many such genes were pointed out, and even supposing the manipulation of those genes doesn't cease the getting older method, they supply many worthwhile insights into the mobile mechanisms of getting older. extra lately, curiosity has grew to become to using cloning expertise, stem cellphone research, and genetic manipulation which will produce a good rejuvenation remedy for cells and the physique as a complete.

getting older, Revised variation describes the sphere of gerontology and the numerous theories that scientists have built through the years to provide an explanation for the age-related alterations that happen in approximately all animals.

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Additional resources for Aging: Modern Theories and Therapies (New Biology)

Sample text

But even these technologies, as powerful as they are, will not be enough. Gaining a deep understanding of the basic mechanisms of aging will require detailed information about every gene in our bodies and about what those genes are doing as humans grow old. This information is only now being made available, but over the next 10 years researchers expect to see real gains being made in the field of gerontology. 2 The History of Gerontology G erontology is a branch of the biological sciences devoted to the study of the aging process and its effects on cells and organisms.

One theory of aging suggests that the aging process is caused by subtle disruptions in the normal control of gene expression. At first gerontologists tried to test this assumption by examining the protein products of translation with protein electrophoresis, a technology introduced in the 1960s and refined in 1977. In this procedure proteins are isolated from the tissue of interest and then separated on a small gel slab subjected to an electric field (see Gel Electrophoresis in chapter 10). After separation the gel is stained, dried, and photographed.

Phosphorylating the nucleosomes (adding phosphate groups to the proteins) is like releasing a stretched rubber band: The chromosome contracts to form a compact structure that is 10,000 times shorter than the bare piece of DNA. Just as a suitcase makes it possible for us to take our clothes on a trip, histones and the chromatin structure they produce make it possible for the cell to package its genes in preparation for cell division (see Cell Biology in chapter 10 for additional information). Chromatin compaction, or condensation, is also used during interphase (the period between cell divisions) to help manage the chromosomes.

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Aging: Modern Theories and Therapies (New Biology) by Joseph Panno


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