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Download e-book for iPad: Amiloride-Sensitive Sodium Channels: Physiology and by Dale J. Benos (Eds.)

By Dale J. Benos (Eds.)

ISBN-10: 0080585183

ISBN-13: 9780080585185

ISBN-10: 0120890305

ISBN-13: 9780120890309

ISBN-10: 0121533476

ISBN-13: 9780121533472

Sodium reabsorbing epithelia play a big function in whole-body sodium homeostasis. a few examples of sodium regulating tissues comprise kidney, colon, lung, and sweat ducts. Sodium delivery throughout those membranes is a two-step procedure: access via an amiloride-sensitive sodium channel and go out through the ouabain-sensitive sodium/potassium ATPase. The sodium access channels are the rate-limiting determinant for delivery and are regulated via numerous varied hormones. The sodium channels additionally play an important function in a couple of illness states, like high blood pressure, edema, drug-induced hyperkalemia, and cystic fibrosis. Amiloride-Sensitive Sodium Channels: body structure and practical variety presents the 1st in-depth alternate of rules referring to those sodium channels, their legislation and involvement in basic and pathophysiological events. Key positive factors * Summarizes present nation of amiloride-sensitive sodium channel box * Analyzes structure-function of epithelial sodium channels * Discusses immunolocalization of epithelial sodium channels * Examines hormonal legislation of sodium channels * Discusses sodium channels in lymphocytes, kidney, and lung * Considers mechanosensitivity of sodium channels * presents rules on sodium channels and illness

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Extra resources for Amiloride-Sensitive Sodium Channels: Physiology and Functional Diversity

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1996). , 1996). , 1986), which may contribute to the altered NaCl composition in the airway that contributes to the pathophysiology of cystic fibrosis. To learn how mutations produce altered channel function and disease, we investigated the structure of ENaC. In this chapter, we review the membrane topology, subunit composition, and stoichiometry of ENaC. II. , 1994). In vitro translation of arENaC produced a 73-kDa protein, and an additional 93-kDa protein was produced when arENaC was translated in the presence of microsomal membranes, corresponding to the core-glycosylatedform of the protein (Fig.

Volk, K. , Zeiher, B. , Stokes, J. , and Welsh, M. J. (1995). Mechanism by which Liddle’s syndrome mutations increase activity of a human epithelial Nat channel. ) 83,969-978. Snyder, P. , Prince, L. , Rogers, J. , and Welsh, M. J. (1998). Electrophysiological and biochemical evidence that DEG/ENaC cation channels are composed of nine subunits. J. Biol. Chem. 273, 681-684. Sorscher, E. , Accavitti, M. , Frizzell, R. , and Benos, D. J. (1988). Antibodies against purified epithelial sodium channel protein from bovine renal papilla.

Identification of an amiloride binding domain within the a-subunit of the epithelial Na' channel. J. Biol. Chem. 272, 21075-21083. Kleyman, T. , Kraehenbuhl, J. , and Ernst, S. A. (1991). Characterization and cellular localisation of the epithelial Na' channel. Studies using an anti-Na' channel antibody raised by an anti-idiotypic route. J. B i d . Chem. 266, 3907-3915. Lester, D. , and Garty, H. (1988). Characterization of CAMP-induced activation of epithelial Na' channels. Am. J. Physiol. 254, C802-C808.

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Amiloride-Sensitive Sodium Channels: Physiology and Functional Diversity by Dale J. Benos (Eds.)

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