By Lois A. Lampson (auth.), Ricardo Martínez Murillo, Alfredo Martínez (eds.)
Although the on hand types, no matter if on the mobile, tissue, or animal point, don't precisely characterize the biology of human mind tumors, animal types can supply major insights into those tumors, offering a greater realizing of organic mechanisms underlying tumor iteration, development, angiogenesis, invasion, and metastasis. Animal types of mind Tumors brings jointly advancements and discoveries in “in vivo” experimental tumor examine that experience supplied advances in our figuring out of the mobile and molecular mechanisms curious about the new release, development, and medical end result of mind neoplasms. damaged into handy sections, this thorough quantity contains subject matters similar to animal version insights into human mind neoplasms, the mobile, molecular, and genetic foundation of mind tumors, cures within the remedy of malignant glioma, in addition to imaging applied sciences in animal tumor types, i.e. measuring mind tumor progress and metabolism. Written for the preferred Neuromethods series, chapters comprise the type of distinct description and implementation suggestion that's crucial for attaining winning results.
Authoritative and state of the art, Animal types of mind Tumors offers the major tools had to validate, examine, and distinction the animal version with its proposed human counterpart and extra the knowledge of our personal severe ailments.
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Extra resources for Animal Models of Brain Tumors
This tragedy might have been prevented with greater awareness that GBM cancer cells can metastasize outside the CNS. The VM Mouse Model of Glioblastoma Multiforme 41 Dr. Brent Reynolds, a leader in the stem cell field, mentioned to us that circulating metastatic cells are not uncommon in GBM patients (personal communication). Moreover, extracranial metastasis of brain tumors portends an extremely poor survival, with the vast majority of patients surviving less than 6 months from the diagnosis of metastatic GBM disease (36).
The training of staff for performing a particular procedure. 5. The implementation of a humane endpoint. 8. Humane Endpoints Direct or necessary inhumanities, such as pain, distress, and suffering, may sometimes be unavoidable in animal-based research, and contingent or avoidable inhumanities must always be avoided in animal experiments. A humane endpoint has been defined in different ways by different organisations and individuals (5–8). For purposes of this chapter, a humane endpoint will be defined as the earliest indicator in an animal-based experiment where an experimental animal is experiencing severe pain, distress, and suffering or close to impending death.
Refinement in animal-based research requires knowledge and an assessment of those elements in a research programme that can adversely affect the research animals and should be applied in order to reduce and minimize this negative impact. In this chapter, I have tried to explain refinement and the establishment of humane endpoints, using examples from my own experience and the published scientific literature. By doing so, it is hoped that this information will be useful for assessing the severity of procedures and determining the time point at which humane endpoints should be instituted in animal-based research.
Animal Models of Brain Tumors by Lois A. Lampson (auth.), Ricardo Martínez Murillo, Alfredo Martínez (eds.)